| Effingham to University Place (Washington) | 1,785.79 mi (2,873.94 km) |
| Effingham to Upland (California) | 1,643.40 mi (2,644.79 km) |
| Effingham to Upper Arlington (Ohio) | 298.47 mi (480.34 km) |
| Effingham to Upper Grand Lagoon (Florida) | 638.68 mi (1,027.86 km) |
| Effingham to Upper Montclair (New Jersey) | 768.11 mi (1,236.15 km) |
| Effingham to Urbana (Illinois) | 70.96 mi (114.19 km) |
| Effingham to Urbana (Maryland) | 599.73 mi (965.17 km) |
| Effingham to Urbana (Ohio) | 264.25 mi (425.26 km) |
| Effingham to Urbandale (Iowa) | 325.58 mi (523.97 km) |
| Effingham to Utica (New York) | 745.04 mi (1,199.02 km) |
| Effingham to Uvalde (Texas) | 936.74 mi (1,507.53 km) |
| Effingham to Vacaville (California) | 1,791.44 mi (2,883.05 km) |
| Effingham to Vadnais Heights (Minnesota) | 471.03 mi (758.05 km) |
| Effingham to Vail (Arizona) | 1,333.25 mi (2,145.66 km) |
| Effingham to Valdosta (Georgia) | 644.35 mi (1,036.98 km) |
