| Effingham to Superior (Colorado) | 885.59 mi (1,425.22 km) |
| Effingham to Superior (Wisconsin) | 552.81 mi (889.66 km) |
| Effingham to Surprise (Arizona) | 1,376.70 mi (2,215.58 km) |
| Effingham to Susanville (California) | 1,695.72 mi (2,729.00 km) |
| Effingham to Sussex (Wisconsin) | 277.87 mi (447.19 km) |
| Effingham to Suwanee (Georgia) | 429.44 mi (691.12 km) |
| Effingham to Swansea (Illinois) | 86.68 mi (139.50 km) |
| Effingham to Sweetwater (Florida) | 1,036.62 mi (1,668.29 km) |
| Effingham to Sweetwater (Texas) | 806.87 mi (1,298.53 km) |
| Effingham to Sycamore (Illinois) | 198.78 mi (319.90 km) |
| Effingham to Sylacauga (Alabama) | 429.97 mi (691.97 km) |
| Effingham to Sylvania (Ohio) | 311.18 mi (500.79 km) |
| Effingham to Syosset (New York) | 804.42 mi (1,294.59 km) |
| Effingham to Syracuse (New York) | 699.77 mi (1,126.17 km) |
| Effingham to Syracuse (Utah) | 1,246.51 mi (2,006.07 km) |
