| Effingham to Storm Lake (Iowa) | 423.74 mi (681.95 km) |
| Effingham to Storrs (Connecticut) | 875.27 mi (1,408.61 km) |
| Effingham to Stoughton (Wisconsin) | 265.09 mi (426.63 km) |
| Effingham to Stow (Ohio) | 401.64 mi (646.38 km) |
| Effingham to Streamwood (Illinois) | 201.35 mi (324.04 km) |
| Effingham to Streator (Illinois) | 139.24 mi (224.09 km) |
| Effingham to Streetsboro (Ohio) | 407.41 mi (655.66 km) |
| Effingham to Strongsville (Ohio) | 385.39 mi (620.23 km) |
| Effingham to Stuart (Florida) | 952.71 mi (1,533.23 km) |
| Effingham to Stuarts Draft (Virginia) | 519.39 mi (835.88 km) |
| Effingham to Sturgis (Michigan) | 247.69 mi (398.62 km) |
| Effingham to Suamico (Wisconsin) | 381.85 mi (614.53 km) |
| Effingham to Sudley (Virginia) | 594.06 mi (956.04 km) |
| Effingham to Suffern (New York) | 772.74 mi (1,243.60 km) |
| Effingham to Suffolk (Virginia) | 670.04 mi (1,078.33 km) |
