| Effingham to Stephenville (Texas) | 721.89 mi (1,161.77 km) |
| Effingham to Sterling (Colorado) | 782.38 mi (1,259.12 km) |
| Effingham to Sterling (Illinois) | 194.64 mi (313.24 km) |
| Effingham to Sterling (Virginia) | 597.63 mi (961.79 km) |
| Effingham to Sterling Heights (Michigan) | 374.56 mi (602.80 km) |
| Effingham to Steubenville (Ohio) | 428.22 mi (689.15 km) |
| Effingham to Stevens Point (Wisconsin) | 376.88 mi (606.52 km) |
| Effingham to Stevenson Ranch (California) | 1,686.58 mi (2,714.29 km) |
| Effingham to Stillwater (Minnesota) | 465.05 mi (748.42 km) |
| Effingham to Stillwater (Oklahoma) | 509.81 mi (820.46 km) |
| Effingham to Stockbridge (Georgia) | 455.18 mi (732.54 km) |
| Effingham to Stockton (California) | 1,762.39 mi (2,836.29 km) |
| Effingham to Stone Ridge (Virginia) | 589.97 mi (949.47 km) |
| Effingham to Stonecrest (Georgia) | 448.55 mi (721.88 km) |
| Effingham to Stony Brook (New York) | 824.32 mi (1,326.62 km) |
