| Effingham to St. Simons (Georgia) | 681.41 mi (1,096.63 km) |
| Effingham to Stafford (Texas) | 767.67 mi (1,235.44 km) |
| Effingham to Stallings (North Carolina) | 515.31 mi (829.31 km) |
| Effingham to Stamford (Connecticut) | 802.94 mi (1,292.20 km) |
| Effingham to Stanford (California) | 1,816.82 mi (2,923.88 km) |
| Effingham to Stanton (California) | 1,669.07 mi (2,686.11 km) |
| Effingham to Star (Idaho) | 1,474.57 mi (2,373.10 km) |
| Effingham to Starkville (Mississippi) | 391.35 mi (629.82 km) |
| Effingham to State College (Pennsylvania) | 577.64 mi (929.62 km) |
| Effingham to Staten Island (New York) | 769.66 mi (1,238.65 km) |
| Effingham to Statesboro (Georgia) | 597.49 mi (961.57 km) |
| Effingham to Statesville (North Carolina) | 479.93 mi (772.38 km) |
| Effingham to Staunton (Virginia) | 516.19 mi (830.72 km) |
| Effingham to Steamboat Springs (Colorado) | 972.79 mi (1,565.56 km) |
| Effingham to Steiner Ranch (Texas) | 803.67 mi (1,293.38 km) |
