| Effingham to Southern Pines (North Carolina) | 571.74 mi (920.13 km) |
| Effingham to Southfield (Michigan) | 360.89 mi (580.80 km) |
| Effingham to Southgate (Michigan) | 351.87 mi (566.27 km) |
| Effingham to Southlake (Texas) | 641.57 mi (1,032.51 km) |
| Effingham to Spanaway (Washington) | 1,779.25 mi (2,863.42 km) |
| Effingham to Spanish Fork (Utah) | 1,227.40 mi (1,975.32 km) |
| Effingham to Spanish Lake (Missouri) | 91.93 mi (147.94 km) |
| Effingham to Spanish Springs (Nevada) | 1,653.75 mi (2,661.45 km) |
| Effingham to Sparks (Nevada) | 1,657.09 mi (2,666.83 km) |
| Effingham to Spartanburg (South Carolina) | 465.41 mi (749.01 km) |
| Effingham to Spearfish (South Dakota) | 867.51 mi (1,396.13 km) |
| Effingham to Speedway (Indiana) | 131.35 mi (211.39 km) |
| Effingham to Spencer (Iowa) | 441.85 mi (711.08 km) |
| Effingham to Spokane (Washington) | 1,554.30 mi (2,501.40 km) |
| Effingham to Spokane Valley (Washington) | 1,545.20 mi (2,486.75 km) |
