| Effingham to Silver Firs (Washington) | 1,772.55 mi (2,852.64 km) |
| Effingham to Silver Spring (Maryland) | 618.22 mi (994.93 km) |
| Effingham to Silver Springs Shores (Florida) | 785.51 mi (1,264.16 km) |
| Effingham to Silverdale (Washington) | 1,795.47 mi (2,889.53 km) |
| Effingham to Silverton (Oregon) | 1,788.08 mi (2,877.63 km) |
| Effingham to Simi Valley (California) | 1,698.11 mi (2,732.85 km) |
| Effingham to Simpsonville (South Carolina) | 461.23 mi (742.28 km) |
| Effingham to Sioux City (Iowa) | 471.37 mi (758.60 km) |
| Effingham to Sioux Falls (South Dakota) | 522.42 mi (840.76 km) |
| Effingham to Skokie (Illinois) | 205.88 mi (331.34 km) |
| Effingham to Sleepy Hollow (New York) | 786.60 mi (1,265.92 km) |
| Effingham to Slidell (Louisiana) | 614.20 mi (988.46 km) |
| Effingham to Smithfield (North Carolina) | 612.99 mi (986.51 km) |
| Effingham to Smithfield (Utah) | 1,233.68 mi (1,985.42 km) |
| Effingham to Smithville (Missouri) | 322.76 mi (519.43 km) |
