| Effingham to Seymour (Tennessee) | 344.80 mi (554.90 km) |
| Effingham to Shady Hills (Florida) | 816.29 mi (1,313.69 km) |
| Effingham to Shafter (California) | 1,695.09 mi (2,727.99 km) |
| Effingham to Shaker Heights (Ohio) | 403.04 mi (648.63 km) |
| Effingham to Shakopee (Minnesota) | 465.30 mi (748.83 km) |
| Effingham to Sharon (Pennsylvania) | 449.20 mi (722.92 km) |
| Effingham to Sharonville (Ohio) | 222.13 mi (357.49 km) |
| Effingham to Shasta Lake (California) | 1,785.18 mi (2,872.97 km) |
| Effingham to Shawnee (Kansas) | 335.64 mi (540.17 km) |
| Effingham to Shawnee (Oklahoma) | 530.67 mi (854.04 km) |
| Effingham to Sheboygan (Wisconsin) | 322.00 mi (518.21 km) |
| Effingham to Shelby (North Carolina) | 467.39 mi (752.19 km) |
| Effingham to Shelbyville (Indiana) | 150.87 mi (242.80 km) |
| Effingham to Shelbyville (Kentucky) | 189.99 mi (305.76 km) |
| Effingham to Shelbyville (Tennessee) | 275.53 mi (443.42 km) |
