| Effingham to Security-Widefield (Colorado) | 867.93 mi (1,396.80 km) |
| Effingham to Sedalia (Missouri) | 253.37 mi (407.75 km) |
| Effingham to Sedro-Woolley (Washington) | 1,782.57 mi (2,868.76 km) |
| Effingham to Seguin (Texas) | 848.76 mi (1,365.95 km) |
| Effingham to Selden (New York) | 828.41 mi (1,333.20 km) |
| Effingham to Selma (Alabama) | 470.92 mi (757.87 km) |
| Effingham to Selma (California) | 1,695.66 mi (2,728.90 km) |
| Effingham to Selma (Texas) | 861.42 mi (1,386.33 km) |
| Effingham to Seminole (Florida) | 846.58 mi (1,362.43 km) |
| Effingham to Seven Hills (Ohio) | 394.70 mi (635.21 km) |
| Effingham to Seven Oaks (South Carolina) | 539.79 mi (868.71 km) |
| Effingham to Severn (Maryland) | 634.97 mi (1,021.89 km) |
| Effingham to Severna Park (Maryland) | 641.98 mi (1,033.17 km) |
| Effingham to Sevierville (Tennessee) | 352.76 mi (567.71 km) |
| Effingham to Seymour (Indiana) | 143.24 mi (230.53 km) |
