| Effingham to Scottsboro (Alabama) | 338.77 mi (545.19 km) |
| Effingham to Scottsdale (Arizona) | 1,345.47 mi (2,165.32 km) |
| Effingham to Scranton (Pennsylvania) | 696.77 mi (1,121.35 km) |
| Effingham to Seabrook (Maryland) | 627.47 mi (1,009.81 km) |
| Effingham to Seabrook (Texas) | 755.31 mi (1,215.56 km) |
| Effingham to Seaford (New York) | 804.38 mi (1,294.53 km) |
| Effingham to Seagoville (Texas) | 631.91 mi (1,016.95 km) |
| Effingham to Seal Beach (California) | 1,674.40 mi (2,694.68 km) |
| Effingham to Searcy (Arkansas) | 320.17 mi (515.27 km) |
| Effingham to Seaside (California) | 1,812.58 mi (2,917.06 km) |
| Effingham to SeaTac (Washington) | 1,775.94 mi (2,858.10 km) |
| Effingham to Seattle (Washington) | 1,778.53 mi (2,862.27 km) |
| Effingham to Sebastian (Florida) | 910.14 mi (1,464.73 km) |
| Effingham to Sebring (Florida) | 902.12 mi (1,451.83 km) |
| Effingham to Secaucus (New Jersey) | 774.83 mi (1,246.98 km) |
