| Effingham to Savannah (Georgia) | 641.06 mi (1,031.68 km) |
| Effingham to Sayreville (New Jersey) | 760.15 mi (1,223.35 km) |
| Effingham to Sayville (New York) | 826.00 mi (1,329.32 km) |
| Effingham to Scaggsville (Maryland) | 624.85 mi (1,005.60 km) |
| Effingham to Scarsdale (New York) | 790.92 mi (1,272.87 km) |
| Effingham to Schaumburg (Illinois) | 202.57 mi (326.00 km) |
| Effingham to Schenectady (New York) | 803.03 mi (1,292.35 km) |
| Effingham to Schererville (Indiana) | 173.53 mi (279.28 km) |
| Effingham to Schertz (Texas) | 860.43 mi (1,384.73 km) |
| Effingham to Schiller Park (Illinois) | 199.33 mi (320.79 km) |
| Effingham to Schofield Barracks (Hawaii) | 4,219.01 mi (6,789.83 km) |
| Effingham to Scotchtown (New York) | 764.03 mi (1,229.58 km) |
| Effingham to Scottdale (Georgia) | 438.23 mi (705.26 km) |
| Effingham to Scotts Valley (California) | 1,814.93 mi (2,920.85 km) |
| Effingham to Scottsbluff (Nebraska) | 815.17 mi (1,311.89 km) |
