| Effingham to Santa Rosa (California) | 1,829.28 mi (2,943.95 km) |
| Effingham to Santaquin (Utah) | 1,236.26 mi (1,989.58 km) |
| Effingham to Santee (California) | 1,640.03 mi (2,639.37 km) |
| Effingham to Sapulpa (Oklahoma) | 465.79 mi (749.61 km) |
| Effingham to Saraland (Alabama) | 572.15 mi (920.78 km) |
| Effingham to Sarasota (Florida) | 884.43 mi (1,423.35 km) |
| Effingham to Sarasota Springs (Florida) | 887.91 mi (1,428.95 km) |
| Effingham to Saratoga (California) | 1,811.98 mi (2,916.11 km) |
| Effingham to Saratoga Springs (New York) | 814.83 mi (1,311.34 km) |
| Effingham to Saratoga Springs (Utah) | 1,240.74 mi (1,996.78 km) |
| Effingham to Sartell (Minnesota) | 533.86 mi (859.17 km) |
| Effingham to Satellite Beach (Florida) | 882.63 mi (1,420.46 km) |
| Effingham to Sauk Rapids (Minnesota) | 530.85 mi (854.32 km) |
| Effingham to Sault Ste. Marie (Michigan) | 550.75 mi (886.35 km) |
| Effingham to Savage (Minnesota) | 461.00 mi (741.91 km) |
