| Effingham to Orangevale (California) | 1,747.29 mi (2,811.99 km) |
| Effingham to Orchards (Washington) | 1,777.41 mi (2,860.46 km) |
| Effingham to Orcutt (California) | 1,773.82 mi (2,854.69 km) |
| Effingham to Oregon (Ohio) | 321.12 mi (516.79 km) |
| Effingham to Oregon (Wisconsin) | 266.49 mi (428.87 km) |
| Effingham to Oregon City (Oregon) | 1,779.47 mi (2,863.79 km) |
| Effingham to Orem (Utah) | 1,229.60 mi (1,978.85 km) |
| Effingham to Orinda (California) | 1,809.97 mi (2,912.86 km) |
| Effingham to Orland Park (Illinois) | 175.62 mi (282.63 km) |
| Effingham to Orlando (Florida) | 843.27 mi (1,357.11 km) |
| Effingham to Ormond Beach (Florida) | 800.37 mi (1,288.07 km) |
| Effingham to Oro Valley (Arizona) | 1,335.38 mi (2,149.08 km) |
| Effingham to Oroville (California) | 1,755.04 mi (2,824.46 km) |
| Effingham to Oshkosh (Wisconsin) | 338.71 mi (545.10 km) |
| Effingham to Oskaloosa (Iowa) | 262.79 mi (422.91 km) |
