| Effingham to Indianola (Iowa) | 306.42 mi (493.14 km) |
| Effingham to Indio (California) | 1,576.71 mi (2,537.47 km) |
| Effingham to Inglewood (California) | 1,683.97 mi (2,710.08 km) |
| Effingham to Inkster (Michigan) | 350.99 mi (564.86 km) |
| Effingham to Inver Grove Heights (Minnesota) | 456.96 mi (735.40 km) |
| Effingham to Inwood (New York) | 790.70 mi (1,272.51 km) |
| Effingham to Iona (Florida) | 950.54 mi (1,529.74 km) |
| Effingham to Ionia (Michigan) | 322.20 mi (518.53 km) |
| Effingham to Iowa City (Iowa) | 235.07 mi (378.31 km) |
| Effingham to Irmo (South Carolina) | 535.06 mi (861.09 km) |
| Effingham to Irondale (Alabama) | 399.38 mi (642.75 km) |
| Effingham to Ironton (Ohio) | 318.67 mi (512.85 km) |
| Effingham to Irvine (California) | 1,660.42 mi (2,672.20 km) |
| Effingham to Irving (Texas) | 638.78 mi (1,028.02 km) |
| Effingham to Isabela (Puerto Rico) | 1,920.65 mi (3,090.99 km) |
