| Effingham to Hutchinson (Minnesota) | 497.84 mi (801.19 km) |
| Effingham to Hutto (Texas) | 781.21 mi (1,257.23 km) |
| Effingham to Hyattsville (Maryland) | 621.97 mi (1,000.97 km) |
| Effingham to Hybla Valley (Virginia) | 616.52 mi (992.19 km) |
| Effingham to Idaho Falls (Idaho) | 1,251.18 mi (2,013.57 km) |
| Effingham to Idylwood (Virginia) | 608.96 mi (980.03 km) |
| Effingham to Ilchester (Maryland) | 630.75 mi (1,015.09 km) |
| Effingham to Immokalee (Florida) | 969.09 mi (1,559.60 km) |
| Effingham to Imperial (California) | 1,565.31 mi (2,519.12 km) |
| Effingham to Imperial Beach (California) | 1,655.05 mi (2,663.54 km) |
| Effingham to Independence (Kentucky) | 215.07 mi (346.12 km) |
| Effingham to Independence (Missouri) | 310.89 mi (500.33 km) |
| Effingham to Indian Trail (North Carolina) | 517.52 mi (832.87 km) |
| Effingham to Indiana (Pennsylvania) | 508.66 mi (818.60 km) |
| Effingham to Indianapolis (Indiana) | 136.10 mi (219.03 km) |
