| Effingham to Enumclaw (Washington) | 1,759.72 mi (2,831.99 km) |
| Effingham to Ephrata (Pennsylvania) | 661.57 mi (1,064.69 km) |
| Effingham to Erie (Colorado) | 879.11 mi (1,414.80 km) |
| Effingham to Erie (Pennsylvania) | 490.14 mi (788.81 km) |
| Effingham to Erlanger (Kentucky) | 212.80 mi (342.46 km) |
| Effingham to Escanaba (Michigan) | 463.89 mi (746.56 km) |
| Effingham to Escondido (California) | 1,637.10 mi (2,634.66 km) |
| Effingham to Española (New Mexico) | 981.61 mi (1,579.75 km) |
| Effingham to Essex (Maryland) | 647.73 mi (1,042.42 km) |
| Effingham to Essex Junction (Vermont) | 875.48 mi (1,408.95 km) |
| Effingham to Estelle (Louisiana) | 646.92 mi (1,041.12 km) |
| Effingham to Estero (Florida) | 960.04 mi (1,545.04 km) |
| Effingham to Euclid (Ohio) | 407.52 mi (655.83 km) |
| Effingham to Eufaula (Alabama) | 533.51 mi (858.60 km) |
| Effingham to Eugene (Oregon) | 1,804.78 mi (2,904.52 km) |
