| Effingham to Emeryville (California) | 1,816.71 mi (2,923.71 km) |
| Effingham to Emmaus (Pennsylvania) | 698.82 mi (1,124.64 km) |
| Effingham to Emporia (Kansas) | 414.59 mi (667.21 km) |
| Effingham to Encinitas (California) | 1,649.46 mi (2,654.56 km) |
| Effingham to Endicott (New York) | 685.78 mi (1,103.66 km) |
| Effingham to Endwell (New York) | 688.20 mi (1,107.55 km) |
| Effingham to Englewood (Colorado) | 877.65 mi (1,412.44 km) |
| Effingham to Englewood (Florida) | 912.32 mi (1,468.24 km) |
| Effingham to Englewood (New Jersey) | 780.19 mi (1,255.59 km) |
| Effingham to Englewood (Ohio) | 232.02 mi (373.40 km) |
| Effingham to Enid (Oklahoma) | 542.15 mi (872.50 km) |
| Effingham to Ennis (Texas) | 652.16 mi (1,049.55 km) |
| Effingham to Ensley (Florida) | 598.21 mi (962.73 km) |
| Effingham to Enterprise (Alabama) | 559.58 mi (900.56 km) |
| Effingham to Enterprise (Nevada) | 1,471.36 mi (2,367.92 km) |
