| Effingham to Elkhorn (Wisconsin) | 245.34 mi (394.83 km) |
| Effingham to Elko (Nevada) | 1,440.06 mi (2,317.55 km) |
| Effingham to Elkridge (Maryland) | 632.20 mi (1,017.43 km) |
| Effingham to Elkton (Maryland) | 680.28 mi (1,094.80 km) |
| Effingham to Ellensburg (Washington) | 1,690.73 mi (2,720.97 km) |
| Effingham to Ellicott City (Maryland) | 627.00 mi (1,009.06 km) |
| Effingham to Elmhurst (Illinois) | 194.49 mi (313.01 km) |
| Effingham to Elmira (New York) | 648.60 mi (1,043.82 km) |
| Effingham to Elmont (New York) | 793.22 mi (1,276.57 km) |
| Effingham to Elmwood Park (Illinois) | 197.40 mi (317.69 km) |
| Effingham to Elmwood Park (New Jersey) | 772.63 mi (1,243.42 km) |
| Effingham to Elon (North Carolina) | 536.75 mi (863.82 km) |
| Effingham to Eloy (Arizona) | 1,358.06 mi (2,185.59 km) |
| Effingham to Elwood (New York) | 813.06 mi (1,308.49 km) |
| Effingham to Elyria (Ohio) | 373.77 mi (601.52 km) |
