| Effingham to Eggertsville (New York) | 572.61 mi (921.52 km) |
| Effingham to Egypt Lake-Leto (Florida) | 841.83 mi (1,354.79 km) |
| Effingham to El Cajon (California) | 1,640.19 mi (2,639.63 km) |
| Effingham to El Campo (Texas) | 814.53 mi (1,310.85 km) |
| Effingham to El Centro (California) | 1,566.11 mi (2,520.42 km) |
| Effingham to El Cerrito (California) | 1,815.91 mi (2,922.42 km) |
| Effingham to El Dorado (Arkansas) | 467.76 mi (752.79 km) |
| Effingham to El Dorado (Kansas) | 458.25 mi (737.49 km) |
| Effingham to El Dorado Hills (California) | 1,738.38 mi (2,797.65 km) |
| Effingham to El Mirage (Arizona) | 1,372.55 mi (2,208.90 km) |
| Effingham to El Monte (California) | 1,664.21 mi (2,678.28 km) |
| Effingham to El Paso (Texas) | 1,121.66 mi (1,805.14 km) |
| Effingham to El Paso de Robles (California) | 1,769.69 mi (2,848.04 km) |
| Effingham to El Reno (Oklahoma) | 572.88 mi (921.96 km) |
| Effingham to El Segundo (California) | 1,688.02 mi (2,716.60 km) |
