| Effingham to Des Plaines (Illinois) | 204.21 mi (328.64 km) |
| Effingham to Desert Hot Springs (California) | 1,587.63 mi (2,555.04 km) |
| Effingham to DeSoto (Texas) | 647.26 mi (1,041.67 km) |
| Effingham to Destin (Florida) | 614.28 mi (988.59 km) |
| Effingham to Destrehan (Louisiana) | 641.10 mi (1,031.75 km) |
| Effingham to Detroit (Michigan) | 363.40 mi (584.83 km) |
| Effingham to Diamond Bar (California) | 1,654.64 mi (2,662.88 km) |
| Effingham to Diamond Springs (California) | 1,727.05 mi (2,779.41 km) |
| Effingham to Dickinson (North Dakota) | 895.54 mi (1,441.23 km) |
| Effingham to Dickinson (Texas) | 763.67 mi (1,229.01 km) |
| Effingham to Dickson (Tennessee) | 220.93 mi (355.55 km) |
| Effingham to Difficult Run (Virginia) | 601.31 mi (967.71 km) |
| Effingham to Dinuba (California) | 1,684.61 mi (2,711.12 km) |
| Effingham to Discovery Bay (California) | 1,778.77 mi (2,862.66 km) |
| Effingham to Dix Hills (New York) | 812.96 mi (1,308.33 km) |
