| Edwardsville to Yonkers (New York) | 866.41 mi (1,394.35 km) |
| Edwardsville to Yorba Linda (California) | 1,576.51 mi (2,537.15 km) |
| Edwardsville to York (Pennsylvania) | 711.91 mi (1,145.71 km) |
| Edwardsville to Yorktown (Indiana) | 257.21 mi (413.94 km) |
| Edwardsville to Yorkville (Illinois) | 213.84 mi (344.14 km) |
| Edwardsville to Youngstown (Ohio) | 519.53 mi (836.11 km) |
| Edwardsville to Youngsville (Louisiana) | 611.59 mi (984.26 km) |
| Edwardsville to Ypsilanti (Michigan) | 410.55 mi (660.71 km) |
| Edwardsville to Yuba City (California) | 1,691.84 mi (2,722.76 km) |
| Edwardsville to Yucaipa (California) | 1,533.90 mi (2,468.57 km) |
| Edwardsville to Yucca Valley (California) | 1,498.38 mi (2,411.41 km) |
| Edwardsville to Yukon (Oklahoma) | 484.00 mi (778.92 km) |
| Edwardsville to Yulee (Florida) | 738.41 mi (1,188.35 km) |
| Edwardsville to Yuma (Arizona) | 1,438.00 mi (2,314.23 km) |
| Edwardsville to Zachary (Louisiana) | 565.52 mi (910.12 km) |
