| Edwardsville to Worthington (Ohio) | 382.34 mi (615.32 km) |
| Edwardsville to Wright (Florida) | 607.20 mi (977.19 km) |
| Edwardsville to Wyandanch (New York) | 891.74 mi (1,435.12 km) |
| Edwardsville to Wyandotte (Michigan) | 429.47 mi (691.16 km) |
| Edwardsville to Wylie (Texas) | 539.72 mi (868.60 km) |
| Edwardsville to Wyndham (Virginia) | 675.30 mi (1,086.80 km) |
| Edwardsville to Wyoming (Michigan) | 360.81 mi (580.67 km) |
| Edwardsville to Wyomissing (Pennsylvania) | 753.36 mi (1,212.42 km) |
| Edwardsville to Xenia (Ohio) | 329.29 mi (529.94 km) |
| Edwardsville to Yakima (Washington) | 1,630.83 mi (2,624.57 km) |
| Edwardsville to Yankton (South Dakota) | 479.27 mi (771.31 km) |
| Edwardsville to Yauco (Puerto Rico) | 1,996.24 mi (3,212.63 km) |
| Edwardsville to Yazoo City (Mississippi) | 410.42 mi (660.50 km) |
| Edwardsville to Yeadon (Pennsylvania) | 790.14 mi (1,271.61 km) |
| Edwardsville to Yelm (Washington) | 1,731.42 mi (2,786.45 km) |
