| Edwardsville to University Place (Washington) | 1,730.11 mi (2,784.35 km) |
| Edwardsville to Upland (California) | 1,565.08 mi (2,518.76 km) |
| Edwardsville to Upper Arlington (Ohio) | 378.87 mi (609.74 km) |
| Edwardsville to Upper Grand Lagoon (Florida) | 642.81 mi (1,034.51 km) |
| Edwardsville to Upper Montclair (New Jersey) | 848.49 mi (1,365.51 km) |
| Edwardsville to Urbana (Illinois) | 131.98 mi (212.40 km) |
| Edwardsville to Urbana (Maryland) | 678.86 mi (1,092.53 km) |
| Edwardsville to Urbana (Ohio) | 344.69 mi (554.72 km) |
| Edwardsville to Urbandale (Iowa) | 280.58 mi (451.54 km) |
| Edwardsville to Utica (New York) | 824.38 mi (1,326.71 km) |
| Edwardsville to Uvalde (Texas) | 866.24 mi (1,394.09 km) |
| Edwardsville to Vacaville (California) | 1,718.81 mi (2,766.16 km) |
| Edwardsville to Vadnais Heights (Minnesota) | 460.94 mi (741.81 km) |
| Edwardsville to Vail (Arizona) | 1,252.83 mi (2,016.23 km) |
| Edwardsville to Valdosta (Georgia) | 667.30 mi (1,073.91 km) |
