| Edwardsville to Superior (Colorado) | 813.28 mi (1,308.85 km) |
| Edwardsville to Superior (Wisconsin) | 556.16 mi (895.06 km) |
| Edwardsville to Surprise (Arizona) | 1,296.99 mi (2,087.30 km) |
| Edwardsville to Susanville (California) | 1,626.00 mi (2,616.80 km) |
| Edwardsville to Sussex (Wisconsin) | 313.82 mi (505.04 km) |
| Edwardsville to Suwanee (Georgia) | 464.12 mi (746.94 km) |
| Edwardsville to Swansea (Illinois) | 16.69 mi (26.85 km) |
| Edwardsville to Sweetwater (Florida) | 1,058.53 mi (1,703.53 km) |
| Edwardsville to Sweetwater (Texas) | 729.52 mi (1,174.05 km) |
| Edwardsville to Sycamore (Illinois) | 231.74 mi (372.96 km) |
| Edwardsville to Sylacauga (Alabama) | 440.22 mi (708.46 km) |
| Edwardsville to Sylvania (Ohio) | 387.47 mi (623.57 km) |
| Edwardsville to Syosset (New York) | 884.78 mi (1,423.92 km) |
| Edwardsville to Syracuse (New York) | 778.93 mi (1,253.57 km) |
| Edwardsville to Syracuse (Utah) | 1,177.30 mi (1,894.68 km) |
