| Edwardsville to Storm Lake (Iowa) | 380.90 mi (612.99 km) |
| Edwardsville to Storrs (Connecticut) | 955.69 mi (1,538.03 km) |
| Edwardsville to Stoughton (Wisconsin) | 288.24 mi (463.88 km) |
| Edwardsville to Stow (Ohio) | 481.58 mi (775.03 km) |
| Edwardsville to Streamwood (Illinois) | 242.53 mi (390.31 km) |
| Edwardsville to Streator (Illinois) | 172.41 mi (277.47 km) |
| Edwardsville to Streetsboro (Ohio) | 487.29 mi (784.21 km) |
| Edwardsville to Strongsville (Ohio) | 464.95 mi (748.26 km) |
| Edwardsville to Stuart (Florida) | 978.80 mi (1,575.23 km) |
| Edwardsville to Stuarts Draft (Virginia) | 595.03 mi (957.60 km) |
| Edwardsville to Sturgis (Michigan) | 317.94 mi (511.67 km) |
| Edwardsville to Suamico (Wisconsin) | 415.65 mi (668.92 km) |
| Edwardsville to Sudley (Virginia) | 672.19 mi (1,081.78 km) |
| Edwardsville to Suffern (New York) | 853.17 mi (1,373.04 km) |
| Edwardsville to Suffolk (Virginia) | 742.79 mi (1,195.41 km) |
