| Edwardsville to Stephenville (Texas) | 648.28 mi (1,043.31 km) |
| Edwardsville to Sterling (Colorado) | 712.48 mi (1,146.63 km) |
| Edwardsville to Sterling (Illinois) | 208.36 mi (335.32 km) |
| Edwardsville to Sterling (Virginia) | 676.21 mi (1,088.25 km) |
| Edwardsville to Sterling Heights (Michigan) | 448.50 mi (721.79 km) |
| Edwardsville to Steubenville (Ohio) | 508.63 mi (818.56 km) |
| Edwardsville to Stevens Point (Wisconsin) | 396.68 mi (638.39 km) |
| Edwardsville to Stevenson Ranch (California) | 1,608.70 mi (2,588.95 km) |
| Edwardsville to Stillwater (Minnesota) | 456.82 mi (735.17 km) |
| Edwardsville to Stillwater (Oklahoma) | 429.77 mi (691.65 km) |
| Edwardsville to Stockbridge (Georgia) | 485.16 mi (780.78 km) |
| Edwardsville to Stockton (California) | 1,689.08 mi (2,718.32 km) |
| Edwardsville to Stone Ridge (Virginia) | 668.39 mi (1,075.67 km) |
| Edwardsville to Stonecrest (Georgia) | 480.24 mi (772.88 km) |
| Edwardsville to Stony Brook (New York) | 904.70 mi (1,455.98 km) |
