| Edwardsville to St. Simons (Georgia) | 716.17 mi (1,152.56 km) |
| Edwardsville to Stafford (Texas) | 708.55 mi (1,140.30 km) |
| Edwardsville to Stallings (North Carolina) | 574.08 mi (923.90 km) |
| Edwardsville to Stamford (Connecticut) | 883.36 mi (1,421.63 km) |
| Edwardsville to Stanford (California) | 1,743.00 mi (2,805.09 km) |
| Edwardsville to Stanton (California) | 1,590.60 mi (2,559.82 km) |
| Edwardsville to Star (Idaho) | 1,411.45 mi (2,271.51 km) |
| Edwardsville to Starkville (Mississippi) | 373.98 mi (601.86 km) |
| Edwardsville to State College (Pennsylvania) | 658.07 mi (1,059.07 km) |
| Edwardsville to Staten Island (New York) | 849.95 mi (1,367.86 km) |
| Edwardsville to Statesboro (Georgia) | 636.30 mi (1,024.03 km) |
| Edwardsville to Statesville (North Carolina) | 542.18 mi (872.56 km) |
| Edwardsville to Staunton (Virginia) | 592.28 mi (953.18 km) |
| Edwardsville to Steamboat Springs (Colorado) | 902.03 mi (1,451.68 km) |
| Edwardsville to Steiner Ranch (Texas) | 735.13 mi (1,183.08 km) |
