| Edwardsville to St. George (Utah) | 1,287.30 mi (2,071.70 km) |
| Edwardsville to St. Helens (Oregon) | 1,732.89 mi (2,788.82 km) |
| Edwardsville to St. James (New York) | 903.30 mi (1,453.72 km) |
| Edwardsville to St. John (Indiana) | 226.34 mi (364.25 km) |
| Edwardsville to St. Joseph (Missouri) | 266.99 mi (429.68 km) |
| Edwardsville to St. Louis (Missouri) | 17.60 mi (28.32 km) |
| Edwardsville to St. Louis Park (Minnesota) | 459.39 mi (739.32 km) |
| Edwardsville to St. Marys (Georgia) | 731.64 mi (1,177.45 km) |
| Edwardsville to St. Marys (Pennsylvania) | 631.93 mi (1,016.99 km) |
| Edwardsville to St. Matthews (Kentucky) | 238.04 mi (383.09 km) |
| Edwardsville to St. Michael (Minnesota) | 481.82 mi (775.42 km) |
| Edwardsville to St. Paul (Minnesota) | 454.44 mi (731.35 km) |
| Edwardsville to St. Peter (Minnesota) | 434.24 mi (698.84 km) |
| Edwardsville to St. Peters (Missouri) | 33.33 mi (53.64 km) |
| Edwardsville to St. Petersburg (Florida) | 868.93 mi (1,398.41 km) |
