| Edwardsville to Spout Springs (North Carolina) | 650.76 mi (1,047.30 km) |
| Edwardsville to Spring (Texas) | 676.76 mi (1,089.14 km) |
| Edwardsville to Spring Creek (Nevada) | 1,361.94 mi (2,191.84 km) |
| Edwardsville to Spring Hill (Florida) | 830.95 mi (1,337.28 km) |
| Edwardsville to Spring Hill (Tennessee) | 270.09 mi (434.66 km) |
| Edwardsville to Spring Lake (North Carolina) | 655.25 mi (1,054.53 km) |
| Edwardsville to Spring Valley (California) | 1,563.63 mi (2,516.42 km) |
| Edwardsville to Spring Valley (Nevada) | 1,394.52 mi (2,244.26 km) |
| Edwardsville to Spring Valley (New York) | 858.03 mi (1,380.86 km) |
| Edwardsville to Springboro (Ohio) | 312.61 mi (503.10 km) |
| Edwardsville to Springdale (Arkansas) | 290.78 mi (467.96 km) |
| Edwardsville to Springdale (New Jersey) | 804.95 mi (1,295.44 km) |
| Edwardsville to Springdale (Ohio) | 297.72 mi (479.13 km) |
| Edwardsville to Springfield (Illinois) | 69.93 mi (112.55 km) |
| Edwardsville to Springfield (Massachusetts) | 943.77 mi (1,518.86 km) |
