| Edwardsville to Southern Pines (North Carolina) | 634.29 mi (1,020.79 km) |
| Edwardsville to Southfield (Michigan) | 434.75 mi (699.67 km) |
| Edwardsville to Southgate (Michigan) | 427.05 mi (687.26 km) |
| Edwardsville to Southlake (Texas) | 568.41 mi (914.76 km) |
| Edwardsville to Spanaway (Washington) | 1,723.33 mi (2,773.43 km) |
| Edwardsville to Spanish Fork (Utah) | 1,155.94 mi (1,860.31 km) |
| Edwardsville to Spanish Lake (Missouri) | 11.87 mi (19.10 km) |
| Edwardsville to Spanish Springs (Nevada) | 1,582.60 mi (2,546.94 km) |
| Edwardsville to Sparks (Nevada) | 1,585.81 mi (2,552.12 km) |
| Edwardsville to Spartanburg (South Carolina) | 518.63 mi (834.65 km) |
| Edwardsville to Spearfish (South Dakota) | 813.83 mi (1,309.74 km) |
| Edwardsville to Speedway (Indiana) | 211.56 mi (340.48 km) |
| Edwardsville to Spencer (Iowa) | 403.76 mi (649.79 km) |
| Edwardsville to Spokane (Washington) | 1,501.28 mi (2,416.07 km) |
| Edwardsville to Spokane Valley (Washington) | 1,492.25 mi (2,401.54 km) |
