| Edwardsville to South Fulton (Georgia) | 466.95 mi (751.48 km) |
| Edwardsville to South Gate (California) | 1,597.81 mi (2,571.43 km) |
| Edwardsville to South Hill (Washington) | 1,717.09 mi (2,763.40 km) |
| Edwardsville to South Holland (Illinois) | 231.11 mi (371.93 km) |
| Edwardsville to South Houston (Texas) | 698.00 mi (1,123.32 km) |
| Edwardsville to South Huntington (New York) | 890.55 mi (1,433.20 km) |
| Edwardsville to South Jordan (Utah) | 1,172.74 mi (1,887.35 km) |
| Edwardsville to South Lake Tahoe (California) | 1,606.33 mi (2,585.15 km) |
| Edwardsville to South Laurel (Maryland) | 706.02 mi (1,136.23 km) |
| Edwardsville to South Lyon (Michigan) | 417.68 mi (672.19 km) |
| Edwardsville to South Miami (Florida) | 1,065.25 mi (1,714.35 km) |
| Edwardsville to South Miami Heights (Florida) | 1,069.65 mi (1,721.44 km) |
| Edwardsville to South Milwaukee (Wisconsin) | 305.51 mi (491.68 km) |
| Edwardsville to South Ogden (Utah) | 1,171.53 mi (1,885.39 km) |
| Edwardsville to South Pasadena (California) | 1,591.98 mi (2,562.05 km) |
