| Edwardsville to Somersworth (New Hampshire) | 1,039.65 mi (1,673.15 km) |
| Edwardsville to Somerton (Arizona) | 1,445.94 mi (2,327.02 km) |
| Edwardsville to Somerville (Massachusetts) | 1,019.26 mi (1,640.33 km) |
| Edwardsville to Somerville (New Jersey) | 825.81 mi (1,329.02 km) |
| Edwardsville to Sonoma (California) | 1,745.92 mi (2,809.78 km) |
| Edwardsville to Soquel (California) | 1,738.19 mi (2,797.34 km) |
| Edwardsville to South Bend (Indiana) | 279.54 mi (449.88 km) |
| Edwardsville to South Bradenton (Florida) | 891.68 mi (1,435.01 km) |
| Edwardsville to South Burlington (Vermont) | 948.12 mi (1,525.85 km) |
| Edwardsville to South Charleston (West Virginia) | 447.79 mi (720.65 km) |
| Edwardsville to South Daytona (Florida) | 839.99 mi (1,351.83 km) |
| Edwardsville to South El Monte (California) | 1,587.57 mi (2,554.94 km) |
| Edwardsville to South Elgin (Illinois) | 237.88 mi (382.84 km) |
| Edwardsville to South Euclid (Ohio) | 484.84 mi (780.27 km) |
| Edwardsville to South Farmingdale (New York) | 887.23 mi (1,427.85 km) |
