| Edwardsville to Smyrna (Delaware) | 771.59 mi (1,241.75 km) |
| Edwardsville to Smyrna (Georgia) | 456.65 mi (734.91 km) |
| Edwardsville to Smyrna (Tennessee) | 272.29 mi (438.21 km) |
| Edwardsville to Snellville (Georgia) | 476.49 mi (766.84 km) |
| Edwardsville to Snoqualmie (Washington) | 1,700.64 mi (2,736.91 km) |
| Edwardsville to Snyder (Texas) | 741.84 mi (1,193.88 km) |
| Edwardsville to Socastee (South Carolina) | 705.47 mi (1,135.35 km) |
| Edwardsville to Socorro (Texas) | 1,040.89 mi (1,675.16 km) |
| Edwardsville to Soddy-Daisy (Tennessee) | 360.68 mi (580.45 km) |
| Edwardsville to Solana Beach (California) | 1,571.60 mi (2,529.24 km) |
| Edwardsville to Soledad (California) | 1,715.28 mi (2,760.47 km) |
| Edwardsville to Solon (Ohio) | 485.79 mi (781.81 km) |
| Edwardsville to Somers Point (New Jersey) | 825.05 mi (1,327.78 km) |
| Edwardsville to Somerset (Kentucky) | 315.81 mi (508.24 km) |
| Edwardsville to Somerset (New Jersey) | 831.24 mi (1,337.75 km) |
