| Edwardsville to Silver Firs (Washington) | 1,718.50 mi (2,765.66 km) |
| Edwardsville to Silver Spring (Maryland) | 696.82 mi (1,121.43 km) |
| Edwardsville to Silver Springs Shores (Florida) | 809.19 mi (1,302.27 km) |
| Edwardsville to Silverdale (Washington) | 1,740.83 mi (2,801.60 km) |
| Edwardsville to Silverton (Oregon) | 1,727.40 mi (2,779.99 km) |
| Edwardsville to Simi Valley (California) | 1,620.18 mi (2,607.42 km) |
| Edwardsville to Simpsonville (South Carolina) | 511.50 mi (823.18 km) |
| Edwardsville to Sioux City (Iowa) | 421.88 mi (678.95 km) |
| Edwardsville to Sioux Falls (South Dakota) | 479.93 mi (772.38 km) |
| Edwardsville to Skokie (Illinois) | 253.37 mi (407.76 km) |
| Edwardsville to Sleepy Hollow (New York) | 867.03 mi (1,395.35 km) |
| Edwardsville to Slidell (Louisiana) | 587.65 mi (945.73 km) |
| Edwardsville to Smithfield (North Carolina) | 679.15 mi (1,092.99 km) |
| Edwardsville to Smithfield (Utah) | 1,166.32 mi (1,877.02 km) |
| Edwardsville to Smithville (Missouri) | 249.43 mi (401.42 km) |
