| Edwardsville to Shoreview (Minnesota) | 463.77 mi (746.37 km) |
| Edwardsville to Shorewood (Illinois) | 210.24 mi (338.35 km) |
| Edwardsville to Shorewood (Wisconsin) | 316.60 mi (509.52 km) |
| Edwardsville to Short Hills (New Jersey) | 841.31 mi (1,353.96 km) |
| Edwardsville to Short Pump (Virginia) | 675.35 mi (1,086.87 km) |
| Edwardsville to Show Low (Arizona) | 1,153.61 mi (1,856.55 km) |
| Edwardsville to Shreveport (Louisiana) | 486.53 mi (782.99 km) |
| Edwardsville to Sicklerville (New Jersey) | 803.80 mi (1,293.59 km) |
| Edwardsville to Sidney (Ohio) | 326.86 mi (526.03 km) |
| Edwardsville to Sierra Madre (California) | 1,584.86 mi (2,550.59 km) |
| Edwardsville to Sierra Vista (Arizona) | 1,248.38 mi (2,009.07 km) |
| Edwardsville to Sierra Vista Southeast (Arizona) | 1,247.02 mi (2,006.89 km) |
| Edwardsville to Signal Hill (California) | 1,599.92 mi (2,574.82 km) |
| Edwardsville to Sikeston (Missouri) | 133.54 mi (214.91 km) |
| Edwardsville to Siloam Springs (Arkansas) | 307.39 mi (494.69 km) |
