| Edwardsville to Shelton (Connecticut) | 906.39 mi (1,458.70 km) |
| Edwardsville to Shelton (Washington) | 1,756.49 mi (2,826.79 km) |
| Edwardsville to Shenandoah (Louisiana) | 582.57 mi (937.55 km) |
| Edwardsville to Shepherdsville (Kentucky) | 238.80 mi (384.31 km) |
| Edwardsville to Sheridan (Wyoming) | 965.39 mi (1,553.65 km) |
| Edwardsville to Sherman (Texas) | 513.67 mi (826.68 km) |
| Edwardsville to Sherrelwood (Colorado) | 804.87 mi (1,295.32 km) |
| Edwardsville to Sherwood (Arkansas) | 298.60 mi (480.55 km) |
| Edwardsville to Sherwood (Oregon) | 1,731.75 mi (2,786.99 km) |
| Edwardsville to Shiloh (Illinois) | 16.94 mi (27.27 km) |
| Edwardsville to Shiloh (Ohio) | 315.68 mi (508.05 km) |
| Edwardsville to Shiloh (Pennsylvania) | 708.73 mi (1,140.60 km) |
| Edwardsville to Shirley (New York) | 917.44 mi (1,476.47 km) |
| Edwardsville to Shively (Kentucky) | 229.40 mi (369.18 km) |
| Edwardsville to Shoreline (Washington) | 1,726.15 mi (2,777.97 km) |
