| Edwardsville to Seymour (Tennessee) | 396.49 mi (638.08 km) |
| Edwardsville to Shady Hills (Florida) | 835.03 mi (1,343.84 km) |
| Edwardsville to Shafter (California) | 1,618.35 mi (2,604.49 km) |
| Edwardsville to Shaker Heights (Ohio) | 482.45 mi (776.42 km) |
| Edwardsville to Shakopee (Minnesota) | 450.63 mi (725.22 km) |
| Edwardsville to Sharon (Pennsylvania) | 529.32 mi (851.86 km) |
| Edwardsville to Sharonville (Ohio) | 301.34 mi (484.96 km) |
| Edwardsville to Shasta Lake (California) | 1,716.17 mi (2,761.91 km) |
| Edwardsville to Shawnee (Kansas) | 259.60 mi (417.79 km) |
| Edwardsville to Shawnee (Oklahoma) | 451.91 mi (727.28 km) |
| Edwardsville to Sheboygan (Wisconsin) | 361.36 mi (581.55 km) |
| Edwardsville to Shelby (North Carolina) | 524.40 mi (843.94 km) |
| Edwardsville to Shelbyville (Indiana) | 231.18 mi (372.05 km) |
| Edwardsville to Shelbyville (Kentucky) | 260.42 mi (419.11 km) |
| Edwardsville to Shelbyville (Tennessee) | 299.45 mi (481.91 km) |
