| Edwardsville to Security-Widefield (Colorado) | 792.47 mi (1,275.35 km) |
| Edwardsville to Sedalia (Missouri) | 175.04 mi (281.69 km) |
| Edwardsville to Sedro-Woolley (Washington) | 1,730.07 mi (2,784.28 km) |
| Edwardsville to Seguin (Texas) | 781.78 mi (1,258.15 km) |
| Edwardsville to Selden (New York) | 908.78 mi (1,462.54 km) |
| Edwardsville to Selma (Alabama) | 470.65 mi (757.44 km) |
| Edwardsville to Selma (California) | 1,620.19 mi (2,607.45 km) |
| Edwardsville to Selma (Texas) | 793.53 mi (1,277.06 km) |
| Edwardsville to Seminole (Florida) | 862.53 mi (1,388.11 km) |
| Edwardsville to Seven Hills (Ohio) | 474.21 mi (763.17 km) |
| Edwardsville to Seven Oaks (South Carolina) | 590.52 mi (950.35 km) |
| Edwardsville to Severn (Maryland) | 713.83 mi (1,148.80 km) |
| Edwardsville to Severna Park (Maryland) | 720.77 mi (1,159.97 km) |
| Edwardsville to Sevierville (Tennessee) | 405.62 mi (652.78 km) |
| Edwardsville to Seymour (Indiana) | 220.60 mi (355.02 km) |
