| Edwardsville to Scottsboro (Alabama) | 360.10 mi (579.52 km) |
| Edwardsville to Scottsdale (Arizona) | 1,265.66 mi (2,036.88 km) |
| Edwardsville to Scranton (Pennsylvania) | 777.20 mi (1,250.78 km) |
| Edwardsville to Seabrook (Maryland) | 706.05 mi (1,136.28 km) |
| Edwardsville to Seabrook (Texas) | 698.55 mi (1,124.21 km) |
| Edwardsville to Seaford (New York) | 884.69 mi (1,423.77 km) |
| Edwardsville to Seagoville (Texas) | 561.14 mi (903.06 km) |
| Edwardsville to Seal Beach (California) | 1,595.91 mi (2,568.37 km) |
| Edwardsville to Searcy (Arkansas) | 263.56 mi (424.16 km) |
| Edwardsville to Seaside (California) | 1,737.72 mi (2,796.59 km) |
| Edwardsville to SeaTac (Washington) | 1,720.86 mi (2,769.45 km) |
| Edwardsville to Seattle (Washington) | 1,723.87 mi (2,774.30 km) |
| Edwardsville to Sebastian (Florida) | 936.89 mi (1,507.78 km) |
| Edwardsville to Sebring (Florida) | 923.63 mi (1,486.44 km) |
| Edwardsville to Secaucus (New Jersey) | 855.19 mi (1,376.30 km) |
