| Edwardsville to Savannah (Georgia) | 680.71 mi (1,095.50 km) |
| Edwardsville to Sayreville (New Jersey) | 840.39 mi (1,352.47 km) |
| Edwardsville to Sayville (New York) | 906.33 mi (1,458.60 km) |
| Edwardsville to Scaggsville (Maryland) | 703.71 mi (1,132.51 km) |
| Edwardsville to Scarsdale (New York) | 871.33 mi (1,402.27 km) |
| Edwardsville to Schaumburg (Illinois) | 245.14 mi (394.51 km) |
| Edwardsville to Schenectady (New York) | 882.89 mi (1,420.88 km) |
| Edwardsville to Schererville (Indiana) | 229.52 mi (369.37 km) |
| Edwardsville to Schertz (Texas) | 792.74 mi (1,275.78 km) |
| Edwardsville to Schiller Park (Illinois) | 245.53 mi (395.13 km) |
| Edwardsville to Schofield Barracks (Hawaii) | 4,144.01 mi (6,669.14 km) |
| Edwardsville to Scotchtown (New York) | 844.46 mi (1,359.03 km) |
| Edwardsville to Scottdale (Georgia) | 469.71 mi (755.92 km) |
| Edwardsville to Scotts Valley (California) | 1,740.63 mi (2,801.27 km) |
| Edwardsville to Scottsbluff (Nebraska) | 750.00 mi (1,207.00 km) |
