| Edwardsville to Santa Rosa (California) | 1,756.94 mi (2,827.51 km) |
| Edwardsville to Santaquin (Utah) | 1,164.52 mi (1,874.11 km) |
| Edwardsville to Santee (California) | 1,560.74 mi (2,511.76 km) |
| Edwardsville to Sapulpa (Oklahoma) | 386.59 mi (622.16 km) |
| Edwardsville to Saraland (Alabama) | 559.20 mi (899.94 km) |
| Edwardsville to Sarasota (Florida) | 900.31 mi (1,448.91 km) |
| Edwardsville to Sarasota Springs (Florida) | 904.06 mi (1,454.94 km) |
| Edwardsville to Saratoga (California) | 1,737.94 mi (2,796.95 km) |
| Edwardsville to Saratoga Springs (New York) | 894.49 mi (1,439.55 km) |
| Edwardsville to Saratoga Springs (Utah) | 1,169.82 mi (1,882.65 km) |
| Edwardsville to Sartell (Minnesota) | 518.86 mi (835.02 km) |
| Edwardsville to Satellite Beach (Florida) | 910.05 mi (1,464.58 km) |
| Edwardsville to Sauk Rapids (Minnesota) | 516.16 mi (830.67 km) |
| Edwardsville to Sault Ste. Marie (Michigan) | 602.72 mi (969.98 km) |
| Edwardsville to Savage (Minnesota) | 447.07 mi (719.49 km) |
