| Edwardsville to Sanford (Maine) | 1,048.23 mi (1,686.96 km) |
| Edwardsville to Sanford (North Carolina) | 637.19 mi (1,025.46 km) |
| Edwardsville to Sanger (California) | 1,614.96 mi (2,599.03 km) |
| Edwardsville to Santa Ana (California) | 1,586.16 mi (2,552.67 km) |
| Edwardsville to Santa Barbara (California) | 1,668.75 mi (2,685.59 km) |
| Edwardsville to Santa Clara (California) | 1,733.30 mi (2,789.47 km) |
| Edwardsville to Santa Clara (Oregon) | 1,743.01 mi (2,805.10 km) |
| Edwardsville to Santa Clarita (California) | 1,603.11 mi (2,579.96 km) |
| Edwardsville to Santa Cruz (California) | 1,743.12 mi (2,805.29 km) |
| Edwardsville to Santa Fe (New Mexico) | 904.82 mi (1,456.17 km) |
| Edwardsville to Santa Fe (Texas) | 712.20 mi (1,146.18 km) |
| Edwardsville to Santa Fe Springs (California) | 1,591.10 mi (2,560.63 km) |
| Edwardsville to Santa Maria (California) | 1,696.55 mi (2,730.34 km) |
| Edwardsville to Santa Monica (California) | 1,611.44 mi (2,593.37 km) |
| Edwardsville to Santa Paula (California) | 1,635.19 mi (2,631.58 km) |
