| Edwardsville to San Luis Obispo (California) | 1,701.70 mi (2,738.62 km) |
| Edwardsville to San Marcos (California) | 1,563.44 mi (2,516.12 km) |
| Edwardsville to San Marcos (Texas) | 764.39 mi (1,230.16 km) |
| Edwardsville to San Marino (California) | 1,589.32 mi (2,557.77 km) |
| Edwardsville to San Mateo (California) | 1,748.76 mi (2,814.36 km) |
| Edwardsville to San Pablo (California) | 1,744.27 mi (2,807.13 km) |
| Edwardsville to San Rafael (California) | 1,753.43 mi (2,821.88 km) |
| Edwardsville to San Ramon (California) | 1,725.54 mi (2,776.99 km) |
| Edwardsville to San Tan Valley (Arizona) | 1,263.51 mi (2,033.43 km) |
| Edwardsville to Sand Springs (Oklahoma) | 383.44 mi (617.08 km) |
| Edwardsville to Sandusky (Ohio) | 426.18 mi (685.87 km) |
| Edwardsville to Sandy (Oregon) | 1,704.18 mi (2,742.61 km) |
| Edwardsville to Sandy (Utah) | 1,166.02 mi (1,876.53 km) |
| Edwardsville to Sandy Springs (Georgia) | 458.31 mi (737.57 km) |
| Edwardsville to Sanford (Florida) | 852.22 mi (1,371.52 km) |
