| Edwardsville to San Diego (California) | 1,568.71 mi (2,524.60 km) |
| Edwardsville to San Diego Country Estates (California) | 1,546.05 mi (2,488.12 km) |
| Edwardsville to San Dimas (California) | 1,573.30 mi (2,531.98 km) |
| Edwardsville to San Fernando (California) | 1,602.83 mi (2,579.50 km) |
| Edwardsville to San Francisco (California) | 1,752.76 mi (2,820.80 km) |
| Edwardsville to San Gabriel (California) | 1,589.21 mi (2,557.58 km) |
| Edwardsville to San Germán (Puerto Rico) | 1,985.99 mi (3,196.14 km) |
| Edwardsville to San Jacinto (California) | 1,536.87 mi (2,473.35 km) |
| Edwardsville to San Jose (California) | 1,727.88 mi (2,780.76 km) |
| Edwardsville to San Juan (Puerto Rico) | 2,010.67 mi (3,235.86 km) |
| Edwardsville to San Juan (Texas) | 991.16 mi (1,595.12 km) |
| Edwardsville to San Juan Capistrano (California) | 1,579.80 mi (2,542.44 km) |
| Edwardsville to San Leandro (California) | 1,738.28 mi (2,797.49 km) |
| Edwardsville to San Lorenzo (California) | 1,737.37 mi (2,796.02 km) |
| Edwardsville to San Luis (Arizona) | 1,449.56 mi (2,332.85 km) |
