| Edwardsville to Salisbury (New York) | 881.43 mi (1,418.52 km) |
| Edwardsville to Salisbury (North Carolina) | 564.99 mi (909.26 km) |
| Edwardsville to Salmon Creek (Washington) | 1,724.74 mi (2,775.70 km) |
| Edwardsville to Salt Lake City (Utah) | 1,170.05 mi (1,883.01 km) |
| Edwardsville to Sammamish (Washington) | 1,710.65 mi (2,753.02 km) |
| Edwardsville to San Angelo (Texas) | 778.49 mi (1,252.86 km) |
| Edwardsville to San Anselmo (California) | 1,756.10 mi (2,826.17 km) |
| Edwardsville to San Antonio (Texas) | 807.75 mi (1,299.94 km) |
| Edwardsville to San Benito (Texas) | 981.21 mi (1,579.11 km) |
| Edwardsville to San Bernardino (California) | 1,544.84 mi (2,486.18 km) |
| Edwardsville to San Bruno (California) | 1,754.00 mi (2,822.79 km) |
| Edwardsville to San Buenaventura (California) | 1,645.96 mi (2,648.91 km) |
| Edwardsville to San Carlos (California) | 1,747.23 mi (2,811.89 km) |
| Edwardsville to San Carlos Park (Florida) | 973.60 mi (1,566.87 km) |
| Edwardsville to San Clemente (California) | 1,578.71 mi (2,540.69 km) |
