| Edwardsville to Saddlebrooke (Arizona) | 1,245.47 mi (2,004.39 km) |
| Edwardsville to Safety Harbor (Florida) | 854.86 mi (1,375.77 km) |
| Edwardsville to Saginaw (Michigan) | 448.12 mi (721.18 km) |
| Edwardsville to Saginaw (Texas) | 581.40 mi (935.67 km) |
| Edwardsville to Sahuarita (Arizona) | 1,269.80 mi (2,043.54 km) |
| Edwardsville to Saks (Alabama) | 419.72 mi (675.48 km) |
| Edwardsville to Salem (Massachusetts) | 1,030.48 mi (1,658.40 km) |
| Edwardsville to Salem (Ohio) | 505.96 mi (814.27 km) |
| Edwardsville to Salem (Oregon) | 1,739.05 mi (2,798.74 km) |
| Edwardsville to Salem (Virginia) | 550.09 mi (885.29 km) |
| Edwardsville to Salem Lakes (Wisconsin) | 276.39 mi (444.81 km) |
| Edwardsville to Salida (California) | 1,680.84 mi (2,705.04 km) |
| Edwardsville to Salina (Kansas) | 410.55 mi (660.72 km) |
| Edwardsville to Salinas (California) | 1,726.48 mi (2,778.49 km) |
| Edwardsville to Salisbury (Maryland) | 777.52 mi (1,251.30 km) |
