| Edwardsville to Reidsville (North Carolina) | 589.44 mi (948.62 km) |
| Edwardsville to Reisterstown (Maryland) | 706.97 mi (1,137.76 km) |
| Edwardsville to Rendon (Texas) | 590.96 mi (951.06 km) |
| Edwardsville to Reno (Nevada) | 1,593.01 mi (2,563.70 km) |
| Edwardsville to Renton (Washington) | 1,716.27 mi (2,762.07 km) |
| Edwardsville to Republic (Missouri) | 220.00 mi (354.06 km) |
| Edwardsville to Reston (Virginia) | 679.56 mi (1,093.65 km) |
| Edwardsville to Revere (Massachusetts) | 1,024.44 mi (1,648.68 km) |
| Edwardsville to Rexburg (Idaho) | 1,179.83 mi (1,898.76 km) |
| Edwardsville to Reynoldsburg (Ohio) | 392.43 mi (631.55 km) |
| Edwardsville to Rialto (California) | 1,550.51 mi (2,495.31 km) |
| Edwardsville to Richardson (Texas) | 550.43 mi (885.83 km) |
| Edwardsville to Richfield (Minnesota) | 453.21 mi (729.37 km) |
| Edwardsville to Richfield (Wisconsin) | 320.30 mi (515.48 km) |
| Edwardsville to Richland (Washington) | 1,568.54 mi (2,524.33 km) |
