| Edwardsville to Pottsville (Pennsylvania) | 742.79 mi (1,195.41 km) |
| Edwardsville to Poughkeepsie (New York) | 869.33 mi (1,399.05 km) |
| Edwardsville to Poulsbo (Washington) | 1,739.68 mi (2,799.74 km) |
| Edwardsville to Poway (California) | 1,559.09 mi (2,509.11 km) |
| Edwardsville to Powder Springs (Georgia) | 450.38 mi (724.81 km) |
| Edwardsville to Powell (Ohio) | 380.18 mi (611.85 km) |
| Edwardsville to Powell (Tennessee) | 378.26 mi (608.74 km) |
| Edwardsville to Prairie Ridge (Washington) | 1,710.59 mi (2,752.93 km) |
| Edwardsville to Prairie Village (Kansas) | 250.34 mi (402.89 km) |
| Edwardsville to Prairieville (Louisiana) | 588.29 mi (946.77 km) |
| Edwardsville to Prattville (Alabama) | 480.24 mi (772.88 km) |
| Edwardsville to Preakness (New Jersey) | 847.80 mi (1,364.40 km) |
| Edwardsville to Prescott (Arizona) | 1,274.38 mi (2,050.92 km) |
| Edwardsville to Prescott Valley (Arizona) | 1,267.18 mi (2,039.33 km) |
| Edwardsville to Prichard (Alabama) | 563.93 mi (907.57 km) |
