| Edwardsville to Oxford (Alabama) | 426.03 mi (685.63 km) |
| Edwardsville to Oxford (Mississippi) | 307.08 mi (494.20 km) |
| Edwardsville to Oxford (Ohio) | 285.17 mi (458.94 km) |
| Edwardsville to Oxnard (California) | 1,645.07 mi (2,647.49 km) |
| Edwardsville to Oxon Hill (Maryland) | 700.31 mi (1,127.03 km) |
| Edwardsville to Ozark (Alabama) | 563.24 mi (906.45 km) |
| Edwardsville to Ozark (Missouri) | 213.72 mi (343.94 km) |
| Edwardsville to Pace (Florida) | 586.92 mi (944.56 km) |
| Edwardsville to Pacific Grove (California) | 1,743.47 mi (2,805.84 km) |
| Edwardsville to Pacifica (California) | 1,756.72 mi (2,827.17 km) |
| Edwardsville to Paducah (Kentucky) | 139.64 mi (224.73 km) |
| Edwardsville to Pahrump (Nevada) | 1,431.72 mi (2,304.13 km) |
| Edwardsville to Painesville (Ohio) | 502.78 mi (809.15 km) |
| Edwardsville to Palatine (Illinois) | 251.48 mi (404.72 km) |
| Edwardsville to Palatka (Florida) | 789.66 mi (1,270.84 km) |
