| Edwardsville to Oswego (Illinois) | 217.89 mi (350.66 km) |
| Edwardsville to Oswego (New York) | 771.06 mi (1,240.90 km) |
| Edwardsville to Otsego (Minnesota) | 484.46 mi (779.66 km) |
| Edwardsville to Ottawa (Illinois) | 187.44 mi (301.66 km) |
| Edwardsville to Ottawa (Kansas) | 284.79 mi (458.33 km) |
| Edwardsville to Ottumwa (Iowa) | 200.70 mi (322.99 km) |
| Edwardsville to Overland (Missouri) | 21.59 mi (34.75 km) |
| Edwardsville to Overland Park (Kansas) | 252.98 mi (407.12 km) |
| Edwardsville to Overlea (Maryland) | 722.88 mi (1,163.37 km) |
| Edwardsville to Oviedo (Florida) | 862.74 mi (1,388.44 km) |
| Edwardsville to Owasso (Oklahoma) | 363.82 mi (585.50 km) |
| Edwardsville to Owatonna (Minnesota) | 402.75 mi (648.16 km) |
| Edwardsville to Owensboro (Kentucky) | 171.30 mi (275.69 km) |
| Edwardsville to Owings Mills (Maryland) | 708.21 mi (1,139.76 km) |
| Edwardsville to Owosso (Michigan) | 419.88 mi (675.74 km) |
